---
title: Supermicro 5U PCIe GPU Servers Using AMD Instinct™ MI350P GPUs Provides Ready-to-Deploy Enterprise AI for Your Existing Infrastructure
description: Supermicro 5U PCIe GPU servers with AMD Instinct MI350P GPUs offer ready-to-deploy enterprise AI. Scale generative and agentic AI workloads with up to 10 GPUs in existing racks.
---

[Supermicro Data Center Stories](https://learn-more.supermicro.com/data-center-stories)

# [Supermicro 5U PCIe GPU Servers Using AMD Instinct™ MI350P GPUs Provides Ready-to-Deploy Enterprise AI for Your Existing Infrastructure](https://learn-more.supermicro.com/data-center-stories/supermicro-5u-pcie-gpu-servers-amd-instinct-mi350p-enterprise-ai)

 Written by [Supermicro Experts](https://learn-more.supermicro.com/data-center-stories/author/supermicro-experts) | May 7, 2026 3:00:01 PM

Supermicro’s latest 5U PCIe GPU servers are optimized to deliver the full power of AMD’s new Instinct™ MI350P PCIe GPUs, giving enterprises a fast, cost-effective way to scale generative and agentic AI workloads without redesigning their data centers.

## **AI Performance That Fits Your Racks**

The new AMD Instinct MI350P PCIe cards are designed as drop-in accelerators for standard air-cooled servers. Supermicro’s [AS-5126GS-TNRT](https://www.supermicro.com/en/products/system/gpu/5u/as-5126gs-tnrt) and [AS-5126GS-TNRT2](https://www.supermicro.com/en/products/system/gpu/5u/as-5126gs-tnrt2) servers take full advantage of this flexibility, supporting up to 10 MI350P GPUs per server while staying within existing power and cooling envelopes.

Powered by dual [AMD EPYC 9005 processors](https://www.supermicro.com/en/products/aplus) (up to 384 cores), these systems deliver exceptional performance and efficiency for AI inference, RAG pipelines, and agentic AI workloads — all within your current rack infrastructure.

## **Maximum Performance. Maximum ROI**

By combining Supermicro’s high-density PCIe GPU platform with the MI350P’s industry-leading 144 GB HBM3e memory, 600W TDP, and support for low-precision MXFP4/MXFP6 formats, enterprises gain:

- ### Superior tokens-per-dollar economics and lower total cost of ownership
- ### Higher throughput per server, reducing footprint and licensing costs
- ### Faster time from evaluation to production

## **Built on an Open, Enterprise-Ready Ecosystem**

Supermicro servers using [AMD Instinct MI350P GPUs](https://www.supermicro.com/en/products/aplus) and the open-source ROCm software stack give you full vendor independence and zero licensing fees. The fully integrated AI software stack supports PyTorch, TensorFlow, vLLM, and more — making deployment and workload migration simple and cost-effective.

## **Server Highlights**

See the Supermicro 5U PCIe GPU servers using AMD Instinct MI350P GPUs delivering enterprise AI performance firsthand — watch our new video below to experience the drop-in deployment, up to 10-GPU density, and high-throughput inference performance inside existing racks.

- ### [**AS-5126GS-TNRT**](https://www.supermicro.com/en/products/system/gpu/5u/as-5126gs-tnrt): Dual-root PCIe architecture with direct 16-lane CPU-to-GPU connectivity for 8 GPUs
- ### [**AS-5126GS-TNRT2**](https://www.supermicro.com/en/products/system/gpu/5u/as-5126gs-tnrt2): PCIe-switched dual-root topology supporting up to 10 GPUs
- ### Up to 8 or 12 hot-swap NVMe/SATA drives (front-accessible) for flexible storage
- ### Designed for seamless integration into standard air-cooled racks

## **Deploy Enterprise AI Where You Are Today**

With Supermicro and the new AMD Instinct MI350P PCIe GPUs, organizations can immediately scale AI capabilities inside their existing data centers — delivering more performance, better efficiency, and faster ROI.

For more information on Supermicro’s AMD Instinct MI350P solutions, visit: [www.supermicro.com/aplus](https://www.supermicro.com/aplus)

[View full post](https://learn-more.supermicro.com/data-center-stories/supermicro-5u-pcie-gpu-servers-amd-instinct-mi350p-enterprise-ai)

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